January 17, 2018

Health roundup: Alzheimer's edition

Alzheimer's breakthrough: Scientists discover the disease's 'ground zero' in a vulnerable set of immune cells

Alzheimer's disease is caused by immune cells in the brain triggered by inflammation, according to a breakthrough discovery. Experiments found destroying specific cells - known as microglia - reduced the formation of clumps of amyloid beta that form in Alzheimer's and destroy memory. These are the rogue proteins believed to lie at the root of the devastating neurological illness.  The researchers found the microglia release specks of a protein called ASC in response to it. They stick to the amyloid beta protein - boosting its production.

Prof Heneka, of the University of Bonn, Germany, said this may even occur in the very early stages of Alzheimer's. In tests an antibody that blocked ASC from binding to amyloid beta stopped it from forming into damaging clumps. The study published in Nature found this worked in live mice as well as cells grown in the laboratory.

Speaking from Germany, Prof Heneka said: 'The hope would be to interfere with disease progression and spreading of pathology by counteracting or interfering with the NLRP3 inflammasome or ASC specks. 'I would hope - given it is possible to develop a safe and brain penetrant NLRP3 inhibitor - this could be tested in the next five to 10 years from now.'

A Diabetes Drug Has 'Significantly Reversed Memory Loss' in Mice With Alzheimer's

A drug developed for type 2 diabetes has "significantly reversed memory loss" in mice with Alzheimer's disease, and researchers now want to test it on humans. The treatment is exciting for scientists because it works by protecting the brain cells attacked by Alzheimer's disease in three separate ways, rather than relying on a single approach. The drug, which is referred to only as 'triple receptor agonist', or TA, in the paper, acts in multiple ways to protect the brain from degeneration, by activating GIP-1, GIP, and glucagon receptors at the same time.  And seeing as the drug has already been tested and approved for use in humans, it's something that could hit the market a lot faster than other experimental treatment options.....

Alzheimer’s drug turns back clock in powerhouse of cell

Researchers identify molecular target of J147, which is nearing clinical trials to treat Alzheimer’s disease.  The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans. Now scientists have solved the puzzle of what, exactly, J147 does. They report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.

Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer's disease.  While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer's disease and could provide clues to developing novel therapeutics for the disorder....Schubert emphasized that his team's findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.

In separate but related research, his lab found an Alzheimer's drug candidate called J147 that also removes amyloid beta from nerve cells and reduces the inflammatory response in both nerve cells and the brain. It was the study of J147 that led the scientists to discover that endocannabinoids are involved in the removal of amyloid beta and the reduction of inflammation.

Alzheimer's-causing proteins can spread through blood, alarming new study shows

For the first time ever, scientists have shown that healthy mice who shared blood with Alzheimer's-suffering mice also developed the disease. It showed that dangerous beta-amyloid proteins could travel through blood. The team in Canada surgically attached the two mice - one healthy, one suffering - found that the healthy mouse who shared blood with a mouse with Alzheimer's plaques did indeed develop plaques of beta-amyloid protein in their blood. The finding emerged from their study which also showed that Alzheimer's could start in other parts of the body - like the liver or kidney - before traveling up to the brain like cancer.  However, lead author Professor Weihong Song said people should not be alarmed about Alzheimer’s being ‘caught’ by people who have had blood transfusions.

'Rusty' Brains Linked to Alzheimer's

Cleaning out ‘rust’ from the brain could be a way to slow and even prevent the degenerative disease Alzheimer’s, according to new research that pinpoints iron as its so-far elusive potential driver.  Previous research has long linked Alzheimer’s to a build-up in amyloid protein fragments in the brain that are normally broken down in healthy brains. But efforts to treat Alzheimer’s by using drugs that reduce amyloid levels have so far failed, leading to speculation that something else is driving the disease.

New research from the Florey Institute of Neuroscience and Mental Health and the University of Melbourne has found that iron might be the culprit. Iron has a special property that allows it to exchange electrons, which is crucial in allowing our bodies to generate energy from oxygen and fuels such as sugars. But it can also damage neurons in the same way that iron metal rusts in the presence of oxygen.
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The researchers used cutting edge magnetic resonance imaging techniques to measure iron levels in the brain. They found that people with high levels of iron in combination with high levels of amyloid were suffering rapid cognitive decline, but that people with high levels of amyloid but low levels of iron in the brain, were stable. They are now going to carry out a five year trial to test whether an anti-iron drug can slow the progress of Alzheimer’s, in what would be a major breakthrough in finding a treatment.

Dr Ayton cautions that the amount of iron in a person’s brain appears unrelated to their iron intake or iron levels in the blood. People therefore shouldn’t be cutting down on iron in response to these results. It also means that levels of iron in the blood aren’t an indicator of Alzheimer’s risk.

Healthy brain structures may prevent development of Alzheimer's disease

Researchers analyzed brain samples from patients at memory clinics and found that the presence of healthy dendritic spines -- connections between neurons -- provide protection against Alzheimer's in people whose brains have proteins associated with the disease.  The study's lead author, Jeremy Herskowitz, an assistant professor with the University of Alabama at Birmingham School of Medicine's department of neurology said, "One of the precursors of Alzheimer's is the development in the brain of proteins called amyloid and tau, which we refer to as the pathology of Alzheimer's. "However, about 30 percent of the aging population have amyloid and tau buildup but never develop dementia. Our study showed that these individuals had larger, more numerous dendritic spines than those with dementia, indicating that spine health plays a major role in the onset of disease.....The new findings provide "a target for drugs that would be designed to support and maintain dendritic spine health in an effort to rebuild neurons or prevent their loss."

Neurons, which are brain cells, are constantly sending out dendritic spines in search of other neurons. When they connect, a synapse -- an exchange of information -- occurs between neurons. This is the basis for memory and learning, the researchers explained. Healthy dendritic spines could be genetic, or the result of beneficial lifestyle habits -- such as good diet and exercise -- which are known to reduce the risk of dementia.

Lupus increases risk of dementia by more than 50%:

In a study of more than 7,000 people, researchers from Israel found that dementia was 51 percent more common among people with lupus and that lupus patients of ALL ages are more likely to suffer crippling memory loss. The autoimmune disease is hard to diagnose, because it comes with so many symptoms, sometimes including a 'brain fog'. Corticosteroids are used to treat lupus, but can also cause memory problems.

Loud Snorers face a higher risk of Alzheimer's - but treatments for sleep apnea could lower risk of the disease

A two-year study study by New York University researchers of 208 people between ages 55 and 90  found that those with sleep apnea  are at higher risk of  developing Alzheimer's disease. The link was found in 104 people.  This is due to a build up of a toxic protein in their brain called beta-amyloid which triggers Alzheimer's, the progressive brain disease known for slowly causing impairment in memory and cognitive function.

But experts say there is a silver lining: the study showed treatments used to calm the snoring and increase oxygen flow may be able to prevent Alzheimer's disease.  If left untreated, the oxygen deprivation from sleep apnea can result in a growing number of health problems, including high blood pressure, stroke, heart failure, diabetes and heart attacks.

The over 50s can significantly lower their risk of dementia by exercising regularly

Staying active in later life could protect against dementia, as frail older people more than triple their risk of the disease.  A study has found people classed as frail in middle and old age are 3.5 times more likely to be diagnosed with Alzheimer’s disease or dementia a decade later.  This may come from insulin resistance, which makes people frail by speeding up the natural loss of muscle mass which happens in older age.  People with muscle weakness are more likely to have high blood sugar levels, caused by their resistance to insulin, which is also a cause of dementia.  Frail people also suffer from inflammation, which is a reaction of the immune system believed to lead to the brain changes seen in dementia.

Bill Gates is now tackling Alzheimer’s with a huge investment in dementia research

The billionaire is investing $50 million of his personal money in the London-based Dementia Discovery Fund, which is a private-public collaboration that invests in innovative dementia research. He plans to invest at least another $50 million into other startups that are working on “less mainstream” approaches, but these have not yet been identified.
Posted by Jill Fallon at 1:04 PM | Permalink

Gum Disease increases Cancer Risk

Severe gum disease could lead to pancreatic cancer, one of the deadliest and most vicious forms of cancer, two major new studies conclude.

Severe gum disease could lead to one of the deadliest types of cancer, two major studies have concluded. The bacteria responsible for periodontitis, which can be killed through brushing teeth, play a role in pancreatic cancer. Scientists claim it is the first evidence that the bacteria can spread from the mouth to other parts of the body and cause tumors.

Helsinki University researchers used data from 70,000 adults to make their findings - considered to be the first of their kind. They found a clear link between periodontitis and cancer mortality, with the biggest association recorded for the pancreatic form. The findings, made by Finnish researchers, adds to the ever-growing list of cancers that are now linked to gum disease. It offers hope of a cheap way of screening for pancreatic cancer, which is known for being vicious and having low survival rates.  Severe gum disease, known as periodontitis, can affect the bones in people's jaws and cause teeth to fall out. Previous research reveals up to 54 per cent of adults in the UK have gum disease to some extent. Several other scientific trials have shown gum disease can increase the risk of lung, gallbladder and throat cancers, as well as melanoma.

A recent, small study in Brazil finds that Gum disease increases women's risk of breast cancer up to three times

This is thought to be due to the bacteria that causes inflammation in the mouth entering the circulation via the gums and going into breast tissue, which can result in cancer. Speaking of the study's findings, Dr Nigel Carter OBE, CEO of the Oral Health Foundation, said: 'Interestingly, this research shows that there is evidence to support the theory that gum disease can have a much larger impact on the health of our whole body.'

Mayo Clinic on Prevention
The best way to prevent periodontitis is to follow a program of good oral hygiene, one that you begin early and practice consistently throughout life.

Good oral hygiene. That means brushing your teeth for two minutes at least twice daily — in the morning and before going to bed — and flossing at least once a day. Flossing before you brush allows you to clean away the loosened food particles and bacteria.
Regular dental visits. See your dentist or dental hygienist regularly for cleanings, usually every six to 12 months. If you have risk factors that increase your chance of developing periodontitis — such as having dry mouth, taking certain medications or smoking — you may need professional cleaning more often.
Posted by Jill Fallon at 12:12 PM | Permalink

Manhood and Alpha Males

Manhood is Not Natural

Manhood is not natural, but it is essential. No society can endure if it does not harness male sexual energy and teach men to take care of the children they father and the women who bear them.

As George Gilder explains pointedly in Men and Marriage, "Unlike a woman, a man has no civilized role or agenda inscribed in his body."  The boy has no onboard GPS directing him toward his future.  His transition into manhood can only come into being with significant, intentional work by other men.  As a behavior, manhood must be learned, proven, and earned.  As an identity, manhood must be bestowed by a boy's father and the community's larger fraternity of men.  His mother can only affirm it.  She cannot bequeath it....

Maleness just happens, but manhood does not.  The first is a biological event, while the second is a developed character quality.  When manhood is not formed and cultivated, males fail to mature, resulting in the "perpetual adolescence" or "failure to launch" that plagues our culture....

The human male nature doesn't naturally go in the direction civilization requires; it requires the direction of other men.  Unlike the female nature, which tends to exist reliably among the median scale of human behavior, the male nature is oriented more toward extremes, for good or bad.....

Manhood must be crafted and refined in order to orient males in pro-social, communitarian directions.  In fact, this is the first work of every civilization.....Ghettos are not created by city planners, crime by the police, or failing health by big pharma.  Each of these social ills arises by inattention to the sexual behaviors of males.  If he doesn't have to marry before having sex (and potentially fathering children), the average man won't.  So he hasn't.  The feminization of poverty and the accompanying declines in female happiness and childhood well-being are the tragic results....

In Manhood in the Making, anthropologist David Gilmore provides an essential insight:

One of my findings here is that manhood ideologies always include a criterion of selfless generosity, even to the point of sacrifice.  Again and again, we find that "real" men are those who give more than they take away; they serve others.  Real men are generous, even to a fault.  Non-men are often those stigmatized as stingy and unproductive.

A good man is the fountain, not the drain.  The formation of such men is the first task of human civilization, and its largest threat when ignored.

A Woman’s Defense of the Alpha Male

In both my personal and professional life, I’m a woman who spends most of her time in the company of alpha males...who embody the traditional traits of Alpha Male dominance: strength, competitiveness, courage, assertiveness, decisiveness, intelligence, aggression…I could go on ad infinitum. These qualities don’t faze me in the slightest. Quite the contrary: I love and absolutely embrace these qualities, both in males and in myself.

As much as he may excel as an athlete or on the battlefield, a true Alpha Male also develops the capacities of character to temper, channel, moderate, and strategically employ this strength. Character – and what is traditionally referred to as “honor” – is central to the way that these men live their lives....

The success and survival of the human race is due as much to woman’s reproductive power as it is due to man’s power to protect and provide. Balance is found by establishing mutual respect; not by diminishing one side or the other.

Posted by Jill Fallon at 11:48 AM | Permalink

January 3, 2018

Health Roundup: Food Edition

Scientists warn against using Canola oil after study reveals it is detrimental to brain health

Canola oil has been heavily marketed as a healthy choice because it is low in saturated fat. But a new study suggests the trendy kitchen staple could worsen memory loss and learning ability in Alzheimer's patients. It may also increase the build-up of plaques in the brain, a hallmark of the degenerative disease. And despite its seemingly wholesome profile, researchers discovered it caused weight gain. The findings suggest for the first time that long-term consumption of canola oil is not beneficial to brain health.

A very low-calorie diet can rapidly REVERSE type 2 diabetes, a new study finds

A very low-calorie diet could rapidly reverse type 2 diabetes, new research suggests....At the Howard Hughes Medical Institute at Yale, a study conducted on mice showed that cutting daily calorie intake by 75 percent lowered blood sugar levels and decreased fat content.  In humans, that would mean turning to a diet of 500 to 800 calories opposed to the average 1,600 to 3,000 calorie intake.

Vitamin C for for Better Bones and Memory

Drinking a couple of glasses of orange juice every day could nearly halve the risk of hip fractures, new research shows. A study of more than 10,000 people has found bones are strengthened by vitamin C, found in oranges, tomatoes, strawberries, kiwi fruit and broccoli...Vitamin C is thought to protect against fragile bones by stimulating cells called osteoblasts to become mature bone cells. Earlier this year a study in the British Journal of Nutrition found eating oranges, grapefruits or lemons packed with citric acid also cut the risk of dementia by almost a quarter. Citric acid contains a chemical called nobiletin which, during animal tests, has been shown to slow or reverse impairment of memory.

The Sugar Industry Conspiracy

In 1965, research funded by the Sugar Research Foundation found sucrose was linked to heart disease. That research was never published.

Eating a handful of nuts twice a week can slash the risk of heart disease

A study of over 200,000 people found those who ate walnuts, almonds, hazelnuts, cashews, pistachios, pecans and peanuts two or more times a week were 23 per cent less likely to develop coronary heart disease and 15 per cent less likely cardiovascular disease.  The same amount of peanuts - which strictly speaking are a legume - also reduced the risk of the conditions by 15 and 13 per cent respectively.

A type of vitamin E found in nuts may prevent asthma attacks by reducing airway inflammation

The form of vitamin E that brought these beneficial effects is gamma-tocopherol, which is abundant in nuts such as walnuts and pecans and in the legume peanut, as well as seed oils such as corn, soybean and sesame. This type has drawn little attention compared with alpha-tocopherol, the form most commonly found in vitamin E supplements. A type of vitamin E found in nuts may prevent asthma attacks by reducing airway inflammation.

The super-fuel designed for the US military that allows you to eat carbs, burn fat and supercharges your brain

Oxford University experts created the supplement based on a decade of $60 million-worth of scientific research.  Now, a San Francisco-based start-up has launched the first commercial version of the drink – dubbed 'keto in a bottle' – made of pure ketone ester... A 2.2-oz shot of Ketone contains 120 calories – roughly the same as a large banana – yet it has no fat, no protein, and no carbohydrates.  Ketones are the tiny, but powerful sources of energy our bodies make naturally when we start using up our fat stores for energy because there are no carbs around. If your diet is low in carbohydrates your body is shifted into 'ketosis', which is when fat stores in the body are broken down into ketones, which fuel the muscles and the brain.....Kieran Clarke, University of Oxford professor of physiological biochemistry, suggests that drinking ketones alongside a carb-rich meal like a piece of pizza provides a performance boost that's 'unlike anything we've ever seen before'.

Gobbling down food increases risk of obesity, heart attack and stroke,

A new study suggests that taking the time to stop and enjoy each mouthful could be the secret of a healthy heart, and a slimmer waistline.  Research by Japanese scientists has found that people who eat slowly and mindfully are less likely to pile on the pounds or develop metabolic syndrome - the name for a cluster of dangerous health problems such as high blood pressure, diabetes and obesity which can damage the heart......Fast eaters who gobbled down their food were five times more likely to develop symptoms which raised their risk of a heart attack, diabetes and stroke. The faster eaters were also more than three times more likely to have gained three stone in weight

Scientific breakthrough cuts cancer risk from bacon

The World Health Organization (WHO) currently warns that bacon cured with nitrites is as dangerous as asbestos and smoking, because the chemicals produce carcinogenic nitrosamines when ingested.  They have estimated that around 34,000 bowel and colon cancer deaths each year are directly attributable to diets which are high in processed meat. The new natural flavoring being used is produced from natural Mediterranean fruit and spice extracts, following ten years of research and development. And crucially, in independent blind taste tests, consumers said it was as good or better than traditionally cured meat. “Our Naked Bacon is not only safer than any other bacon on the market, it also tops the charts in blind taste tests.”
Posted by Jill Fallon at 10:12 AM | Permalink